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N7510

尼卡地平 盐酸盐

≥98%, L-type voltage-dependent calcium channel blocker, powder

别名:

1,4-二氢-2,6-二甲基-4-（3-硝基苯基）-3,5-吡啶二甲酸甲基 2- [甲基（苯甲基）氨基] 乙酯 盐酸盐, YC-93

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关于此项目

经验公式（希尔记法）:
C26H29N3O6 · HCl
化学文摘社编号:
54527-84-3
分子量:
515.99
NACRES:
NA.77
PubChem Substance ID:
24277856
UNSPSC Code:
12352200
EC Number:
259-198-4
MDL number:
MFCD00057327
Assay:
≥98%
Form:
powder
Quality level:
100
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产品名称

尼卡地平 盐酸盐, powder, ≥98%

Quality Level

100

assay

≥98%

form

powder

color

yellow

solubility

DMSO: ~1 mg/mL, 0.1 M NaOH: insoluble, H2O: slightly soluble, methanol: soluble

originator

EKR Therapeutics

storage temp.

2-8°C

SMILES string

Cl[H].COC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OCCN(C)Cc3ccccc3

InChI

1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H

InChI key

AIKVCUNQWYTVTO-UHFFFAOYSA-N

Gene Information

human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

Biochem/physiol Actions

阻断 L 型电压依赖性钙通道；抗高血压药。

Features and Benefits

该化合物由 EKR Therapeutics 开发 。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表， 点击这里 。

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pictograms

Skull and crossbones
GHS06

signalword

Danger

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCG9331
BCCF6860
BCCF6861
BCCF0785
BCBN3159V

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Prasanna P K M Gamage et al.
Journal of cellular and molecular medicine, 22(10), 5160-5164 (2018-07-27)
Ageing is associated with impaired neuromuscular function of the terminal gastrointestinal (GI) tract, which can result in chronic constipation, faecal impaction and incontinence. Interstitial cells of cajal (ICC) play an important role in regulation of intestinal smooth muscle contraction. However
S Thellung et al.
Neurobiology of disease, 7(4), 299-309 (2000-08-31)
Prion diseases are neurodegenerative pathologies characterized by the accumulation, in the brain, of altered forms of the prion protein (PrP), named PrP(Sc). A synthetic peptide homologous to residues 106-126 of PrP (PrP106-126) was reported to maintain the neurodegenerative characteristics of
I Japelj et al.
European journal of pharmacology, 369(1), 43-47 (1999-04-16)
The qualitative and quantitative effects of the (+)-S and (-)-R enantiomers and of the racemic mixture of the Ca2+ channel antagonist, nicardipine, were compared on the isolated porcine coronary artery with intact and removed endothelium. All three forms of nicardipine
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全球贸易项目编号

货号GTIN
N7510-5G04061832962283
N7510-10G04061832962276
N7510-1G04061835506514