Merck
CN

P6001

Sigma-Aldrich

对苯二胺

98% (GC)

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别名:
1,4-二氨基苯, 1,4-苯二胺, 对二氨基苯
线性分子式:
C6H4(NH2)2
CAS号:
分子量:
108.14
Beilstein:
742029
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.83

蒸汽密度

3.7 (vs air)

蒸汽压

1.08 mmHg ( 100 °C)

描述

anti-fade reagent

检测方案

98% (GC)

bp

267 °C (lit.)

mp

138-143 °C (lit.)

SMILES字符串

Nc1ccc(N)cc1

InChI

1S/C6H8N2/c7-5-1-2-6(8)4-3-5/h1-4H,7-8H2

InChI key

CBCKQZAAMUWICA-UHFFFAOYSA-N

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应用

p-苯二胺已被用于:
  • 评估其在朗格汉斯样树突状细胞和自体T细胞中的敏化能力
  • 处理小鼠耳背,以研究其全身免疫作用
  • 加入甘油中,以制备冠状切片玻片,从而用于计算Aβ 斑块

将抗褪色试剂添加到荧光显微镜的封固剂中,防止荧光素和其他荧光染料发生光漂白。

生化/生理作用

p-苯二胺会引起皮肤过敏反应。它被广泛用于染发剂中。它最终会形成Bandrowski′s碱,其被发现是引起过敏的主要原因。p-苯二胺暴露会导致皮炎、荨麻疹和过敏反应。它可起电子供体的作用,已报道其可还原细胞色素c。

注意

储存过程中变黑。

警示用语:

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 1 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

230.0 °F - closed cup

闪点(°C)

110 °C - closed cup

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

危险化学品

分析证书(COA)

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示例

T1503
货号
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包装规格/数量

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  • 如果您查询到的批号为 TO09019TO 等,请输入去除前两位字母的批号:09019TO。

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索取COA

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the solubility of p-Phenylediamine, Product P6001?  

    This product is soluble in ethanol at a concentration of 50 mg/mL, with heating. A clear red to brown solution is observed.

  6. For what applications is p-Phenylediamine, Product P6001, used?

    This is an antifade reagent that is used as a fluorescent stabilizer. Do not confuse the p-phenylenediamine with o-phenylenediamine, which is used as a peroxidase substrate in ELISA procedures.

  7. What is the working concentration for p-Phenylediamine, Product P6001, when used as an antifade agent?  

    J. Immunological Methods, 43, 349 (1981) describes a solution that will reduce the fading of fluorescent materials. The recipe for this solution is: "Add 10 mL of phosphate-buffered saline (0.01 M PO4, pH 7.4 in 0.15 M NaCl) containing 100 mg of p-phenylenediamine to 90 ml of glycerol. The final pH should be adjusted to approximately 8.0 with 0.5 M carbonate-bicarbonate buffer (pH 9.0)".

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

p-Phenylenediamine
DeLeo VA
Dermatitis : Contact, Atopic, Occupational, Drug : Official Journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group, 17(2), 53-55 (2006)
p-Phenylenediamine allergy: the role of Bandrowski's base
White JML, et al.
Clinical and Experimental Allergy, 36(10), 1289-1293 (2006)
In vitro evaluation of the sensitization potential of weak contact allergens using Langerhans-like dendritic cells and autologous T cells
Rougier N, et al.
Toxicology, 145(1), 73-82 (2000)
Identification and quantification of para-phenylenediamine in a temporary black henna tattoo
Brancaccio RR, et al.
American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society, 13(1), 15-18 (2002)
A TgCRND8 mouse model of Alzheimer?s disease exhibits sexual dimorphisms in behavioral indices of cognitive reserve
Granger MW, et al.
Journal of Alzheimer'S Disease, 51(3), 757-773 (2016)

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