PZ0179
伐地昔布
≥98% (HPLC)
别名:
4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide
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关于此项目
经验公式（希尔记法）:
C16H14N2O3S
化学文摘社编号:
分子量:
314.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >25 mg/mL
storage temp.
room temp
SMILES string
Cc1onc(-c2ccccc2)c1-c3ccc(cc3)S(N)(=O)=O
InChI
1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20)
InChI key
LNPDTQAFDNKSHK-UHFFFAOYSA-N
Gene Information
human ... PTGS2(5743)
General description
Valdecoxib (VCX) is a diaryl substituted isoxazole compound. It comprises of sulfonyl propanamide and is a metabolite of parecoxib.
Application
Valdecoxib may be used: as cyclooxygenase-2 (COX-2) inhibitor in fibroblast cells, as an analyte for mass spectrometry analysis, as an standard in ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for quantification of valdecoxib in plasma samples
Biochem/physiol Actions
Valdecoxib is reported to elicit anti-inflammatory, analgesic and antipyretic functionality. It acts as a substrate for the liver enzyme cytochrome P450 2C9(CYP2C9) and cytochrome P450 3A4 (CYP3A4).
Valdecoxib is a non-steroidal anti-inflammatory drug (NSAID), a cyclooxygenase-2 (COX-2) selective inhibitor.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 1 - Repr. 2 - STOT RE 2
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
Discover Bioactive Small Molecules for Lipid Signaling Research