S1688
SR 57227A
solid
别名:
4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride
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关于此项目
经验公式（希尔记法）:
C10H14ClN3 · HCl
化学文摘社编号:
分子量:
248.15
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Quality level:
form
solid
Quality Level
color
white
solubility
H2O: soluble 9 mg/mL
SMILES string
Cl.NC1CCN(CC1)c2cccc(Cl)n2
InChI
1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H
InChI key
FUMINTAAUJUVMP-UHFFFAOYSA-N
Gene Information
human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)
Application
SR 57227A may be used in 5-HT3-mediated cell signaling studies.
Biochem/physiol Actions
Potent and selective 5-HT3 serotonin receptor agonist.
SR 57227A is a highly selective of central and peripheral 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive behavior.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges