S8753
马钱子碱 盐酸盐
glycine receptor antagonist
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关于此项目
经验公式（希尔记法）:
C21H22N2O2 · HCl
化学文摘社编号:
分子量:
370.87
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352210
EC Number:
215-826-9
MDL number:
Quality level:
产品名称
马钱子碱 盐酸盐,
Quality Level
SMILES string
Cl.[H][C@@]12CC(=O)N3c4ccccc4[C@]56CCN7CC(=CCO1)[C@]([H])(C[C@@]57[H])[C@]2([H])[C@]36[H]
InChI
1S/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19-,20-,21+;/m0./s1
InChI key
VLXYTKMPCOQKEM-ZEYGOCRCSA-N
Application
Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions. It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.
Biochem/physiol Actions
Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.
惊厥剂；与 NMDA 受体无关的甘氨酸受体拮抗剂。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
此项目有
Biomarkers in Toxicology null
Horizontal cell feedback without cone type-selective inhibition mediates red?green color opponency in midget ganglion cells of the primate retina
Crook JD, et al.
The Journal of Neuroscience, 31(5), 1762-1772 (2011)
Y-cell receptive field and collicular projection of parasol ganglion cells in macaque monkey retina.
Joanna D Crook et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(44), 11277-11291 (2008-10-31)
The distinctive parasol ganglion cell of the primate retina transmits a transient, spectrally nonopponent signal to the magnocellular layers of the lateral geniculate nucleus. Parasol cells show well-recognized parallels with the alpha-Y cell of other mammals, yet two key alpha-Y
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S8753-100G | 04061832286662 |
| S8753-25G | 04061836961022 |
| S8753-5G | 04061832274171 |