SML2104
Ambrisentan
≥98% (HPLC), Endothelin ETA Receptor Antagonist, powder
别名:
(+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid
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关于此项目
经验公式（希尔记法）:
C22H22N2O4
化学文摘社编号:
分子量:
378.42
NACRES:
NA.77
UNSPSC Code:
41121706
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
产品名称
Ambrisentan, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +160 to +190°, c = 0.5 in methanol
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC1=CC(C)=NC(O[C@@H](C(C2=CC=CC=C2)(OC)C3=CC=CC=C3)C(O)=O)=N1
InChI
1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)
InChI key
OUJTZYPIHDYQMC-UHFFFAOYSA-N
Biochem/physiol Actions
Ambrisentan is an endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH). It is 200-fold selective for the the ETA receptor subtype with a Ki of 1 nM for ETA and a Ki of 195 nM for ETB.
Endothelin ETA Receptor Antagonist; Antihypertensive; Pulmonary Hypertension Treatment
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signalword
Danger
hcodes
Hazard Classifications
Repr. 1A
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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