T4680
特拉唑嗪 盐酸盐
≥98% (TLC), α1-adrenoceptor antagonist, powder
别名:
1-（4-氨基-6,7-二甲氧基-2-喹唑啉基）-4-[（四氢-2-呋喃基）羰基]哌嗪 盐酸盐
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关于此项目
经验公式（希尔记法）:
C19H25N5O4 · HCl
化学文摘社编号:
分子量:
423.89
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
特拉唑嗪 盐酸盐, ≥98% (TLC), powder
Quality Level
assay
≥98% (TLC)
form
powder
color
white to off-white
solubility
H2O: soluble 19.60-20.40 mg/mL, clear, colorless to faintly yellow, methanol: 20 mg/mL, clear, colorless, ethanol: 4 mg/mL
originator
Abbott
SMILES string
Cl[H].COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4
InChI
1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H
InChI key
IWSWDOUXSCRCKW-UHFFFAOYSA-N
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
General description
盐酸特拉唑嗪用于治疗高血压和良性前列腺增生（BPH）。它在肝脏中代谢。它可能与头晕、头痛和虚弱有关。盐酸特拉唑嗪与急性全身性皮疹性脓疱病有关。
Application
盐酸特拉唑嗪已通过反相色谱研究用于正交性和相似性分析5。此外，特拉唑嗪还用于评估化学计量学技术，以确定色谱方法中的正交性和相似性6。
Biochem/physiol Actions
α1-肾上腺素受体拮抗剂。
Preparation Note
盐酸特拉唑嗪可溶于水，浓度为19.60 - 20.40 mg/ml，并产生一种透明无色至淡黄色的溶液。它也可溶于乙醇，浓度为4 mg/mL。此外，根据需要加热，该产品可溶于甲醇，浓度为20 mg/mL，并产生澄清无色的溶液。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Terazosin
Titmarsh S and Monk JP
Drugs, 33(5), 461-477 (1987)
Acute generalized exanthematous pustulosis caused by terazosin hydrochloride.
Speck LM, et al.
J. Drugs Dermatol., 7(4), 395-397 (2008)
E Van Gyseghem et al.
Journal of pharmaceutical and biomedical analysis, 41(1), 141-151 (2005-12-15)
Several chemometric techniques were compared for their performance to determine the orthogonality and similarity between chromatographic systems. Pearson's correlation coefficient (r) based color maps earlier were used to indicate selectivity differences between systems. These maps, in which the systems were
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T4680-250MG | 04061832094038 |
| T4680-50MG | 04061832094045 |