T7697
I-OMe-Tyrphostin AG 538
solid
别名:
α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3′,4′-dihydroxyphenyl)ketone, I-OMe-AG 538
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关于此项目
经验公式（希尔记法）:
C17H12INO5
化学文摘社编号:
分子量:
437.19
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352203
MDL number:
Form:
solid
Quality level:
form
solid
Quality Level
solubility
DMSO: 50 mg/mL
storage temp.
−20°C
SMILES string
COc1cc(cc(I)c1O)\C=C(/C#N)C(=O)c2ccc(O)c(O)c2
InChI
1S/C17H12INO5/c1-24-15-6-9(5-12(18)17(15)23)4-11(8-19)16(22)10-2-3-13(20)14(21)7-10/h2-7,20-21,23H,1H3/b11-4+
InChI key
HSRMHXWCTRFVHK-NYYWCZLTSA-N
Gene Information
human ... IGF1(3479), IGF1R(3480)
Application
I-OMe-Tyrphostin AG 538 has been used as a cell signaling inhibitor in PC-1 cell lines. It has also been used in high throughput screening assays for IGF1R inhibitors.
Biochem/physiol Actions
Insulin growth factor 1 (IGF-1) receptor protein tyrosine kinase inhibitor.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Preparation Note
I-OMe-Tyrphostin AG 538 is soluble in DMSO at 50 mg/ml.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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