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Merck
CN

1316004

USP

氢化可的松

United States Pharmacopeia (USP) Reference Standard

别名:

11β,17α,21-三羟基孕酮-4-烯-3,20-二酮, 17-羟基皮质酮标准液, 4-孕烯-11β,17α,21-三醇-3,20-二酮, 皮质醇标准液, 肯德尔氏化合物F, 赖希斯坦氏物质M

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关于此项目

经验公式(希尔记法):
C21H30O5
化学文摘社编号:
分子量:
362.46
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1354819
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grade

pharmaceutical primary standard

API family

hydrocortisone

manufacturer/tradename

USP

mp

211-214 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

Gene Information

human ... NR3C1(2908)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydrocortisone USP reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare standard stock, standard, and system suitability solution for assay, identification, and performance test by liquid chromatography in accordance with the given below monographs of United States Pharmacopeia (USP) :
  • Hydrocortisone Sodium Succinate for Injection
  • Hydrocortisone Tablets
  • Hydrocortisone Gel
  • Hydrocortisone Lotion

Biochem/physiol Actions

肾上腺皮质分泌的原始糖皮质激素。
肾上腺皮质分泌的原始糖皮质激素。它的抗炎效力是皮质酮的三倍,但 Na2+ 保留效力要低得多。

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.


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pictograms

Health hazard

signalword

Danger

Hazard Classifications

Repr. 1A - STOT RE 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

target_organs

Adrenal gland,Bone marrow

法规信息

监管及禁止进口产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Karin E Koopman et al.
Hepatology (Baltimore, Md.), 60(2), 545-553 (2014-03-29)
American children consume up to 27% of calories from high-fat and high-sugar snacks. Both sugar and fat consumption have been implicated as a cause of hepatic steatosis and obesity but the effect of meal pattern is largely understudied. We hypothesized
Marieke G N Bos et al.
Psychoneuroendocrinology, 46, 102-113 (2014-06-03)
Retrieval of negative emotional memories is often accompanied by the experience of stress. Upon retrieval, a memory trace can temporarily return into a labile state, where it is vulnerable to change. An unresolved question is whether post-retrieval stress may affect
K J Rademaker et al.
Archives of disease in childhood. Fetal and neonatal edition, 93(1), F58-F63 (2007-09-13)
The benefits versus the risks of postnatal administration of steroids in preterm-born infants are still debatable. This review examines the literature on postnatal hydrocortisone treatment for chronic lung disease (CLD) in preterm-born infants with a particular focus on the effects



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货号GTIN
1316004-200MG04061838728470