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81260

Sigma-Aldrich

Poly(ethylene glycol)

average Mn 6,000

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Synonym(s):
PEG
Linear Formula:
H(OCH2CH2)nOH
CAS Number:
25322-68-3
MDL number:
MFCD00081839
PubChem Substance ID:
24887720

form

flakes

mol wt

Mn 5,000-7,000
average Mn 6,000

pH

4.5-7.5

mp

60-63 °C

Ω-end

hydroxyl

α-end

hydroxyl

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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General description

Polyethylene glycol (PEG) is a hydrophilic polymer. It can be easily synthesized by the anionic ring opening polymerization of ethylene oxide, into a range molecular weights and variety of end groups. When crosslinked into networks PEG can have high water content, forming "hydrogels". Hydrogel formation can be initiated by either crosslinking PEG by ionizing radiation or by covalent crosslinking of PEG macromers with reactive chain ends. PEG is a suitable material for biological applications because it does not trigger an immune response.

Application

It has been used to modify therapeutic proteins and peptides to increase their solubility.
Photopolymerized PEG hydrogels have emerging applications in the fabrication of bioactive and immunoisolating barriers for encapsulation of cells.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Joo-Hyung Choi et al.
Veterinary microbiology, 236, 108374-108374 (2019-09-11)
Foot-and-mouth disease (FMD) is a highly contagious disease and causes economic damage at a national level. In particular, the type O FMD virus (FMDV) is a serotype that causes FMD outbreaks most frequently in the world. In recent years, Southeast
Ji Hyeon Hwang et al.
Journal of veterinary science, 20(3), e29-e29 (2019-06-05)
Vaccination is one of the most effective ways of controlling and preventing foot-and-mouth disease (FMD) outbreaks. The effective prevention of this disease requires the use of high-quality vaccines to meet the criteria that enable customers to use them simply. The
Su-Hwa You et al.
Veterinary microbiology, 234, 44-50 (2019-06-20)
Foot-and-mouth disease virus (FMDV) is the cause of an economically devastating disease in major cloven-hoofed livestock. Although type C foot-and-mouth disease (FMD) has not occurred anywhere worldwide since 2004, the antigen bank should be preserved in preparation for an unexpected
Fahad Zadjali et al.
International journal of molecular sciences, 21(5) (2020-03-07)
The tuberous sclerosis complex (Tsc) proteins regulate the conserved mTORC1 growth regulation pathway. We identified that loss of the Tsc2 gene in mouse inner medullary collecting duct (mIMCD) cells induced a greater than two-fold increase in extracellular vesicle (EV) production
Chien-Chi Lin et al.
Biomaterials, 32(36), 9685-9695 (2011-09-20)
Hydrogels provide three-dimensional frameworks with tissue-like elasticity and high permeability for culturing therapeutically relevant cells or tissues. While recent research efforts have created diverse macromer chemistry to form hydrogels, the mechanisms of hydrogel polymerization for in situ cell encapsulation remain
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