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I8377

Iodonitrotetrazolium chloride

Name: Iodonitrotetrazolium chloride
Brand: SIAL

Used in colorimetric assays.

Synonym(s):

2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride, p-Iodonitrotetrazolium Violet, INT

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₃ClIN₅O₂

CAS Number:

146-68-9

Molecular Weight:

505.70

UNSPSC Code:

12171500

NACRES:

NA.47

PubChem Substance ID:

24896138

EC Number:

205-676-2

Beilstein/REAXYS Number:

4093224

MDL number:

MFCD00011961

Assay:

≥98% (TLC)

Form:

powder

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Properties

Quality Level

200

assay

≥98% (TLC)

form

powder

mp

240 °C (dec.) (lit.)

solubility

H₂O: 4 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

2-8°C

SMILES string

[Cl-].[O-][N+](=O)c1ccc(cc1)-[n+]2nc(nn2-c3ccc(I)cc3)-c4ccccc4

InChI

1S/C19H13IN5O2.ClH/c20-15-6-8-16(9-7-15)23-21-19(14-4-2-1-3-5-14)22-24(23)17-10-12-18(13-11-17)25(26)27;/h1-13H;1H/q+1;/p-1

InChI key

JORABGDXCIBAFL-UHFFFAOYSA-M

Description

Application

Iodonitrotetrazolium chloride has been used for the staining of cells. It has been used as a coupling agent in the enzymatic assay of D-arabinitol.

Electron acceptor for the colorimetric assay of various dehydrogenases

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pictograms

GHS02,GHS07

signalword

Danger

hcodes

H228,H335

pcodes

P210 - P240 - P241 - P261 - P271 - P280

Hazard Classifications

Flam. Sol. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

4.1B - Flammable solid hazardous materials

wgk

WGK 3

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Constitutive activation of pp125fak in newly isolated human breast cancer cell lines.

Ignatoski KMW and Ethier SP

Breast Cancer Research and Treatment, 54, 173-173 (1999)

An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates.

Cheng Luo et al.

Journal of biochemical and biophysical methods, 68(2), 101-111 (2006-06-03)

A sensitive spectrophotometric assay for determining mitochondrial malate dehydrogenase activity is described. The assay measures NADH production by coupling it to the reduction of 2-(p-iodophenyl)-3(p-nitrophenyl)-5-phenyl tetrazolium chloride (INT). Via an intermediate electron carrier, either phenazine methosulfate or lipoamide dehydrogenase, INT

Exploration of the diaphorase activity of neutrophil NADPH oxidase.

Alexandra Poinas et al.

European journal of biochemistry, 269(4), 1243-1252 (2002-02-22)

In the O2- generating flavocytochrome b, the membrane-bound component of the neutrophil NADPH oxidase, electrons are transported from NADPH to O2 in the following sequence: NADPH --> FAD --> heme b -->O2. Although p-iodonitrotetrazolium (INT) has frequently been used as

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Global Trade Item Number

SKU	GTIN
I8377-5G	04061835347803
I8377-1G	04061835347797
I8377-250MG	04061833858554
I8377-25G	04061833858561