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T9531

D-(+)-Trehalose dihydrate

Name: <SC>D</SC>-(+)-Trehalose dihydrate
Brand: SIGMA

≥99% (HPLC), from Saccharomyces cerevisiae

Synonym(s):

Trehalose dihydrate, α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₂₂O₁₁ · 2H₂O

CAS Number:

6138-23-4

Molecular Weight:

378.33

UNSPSC Code:

12352201

NACRES:

NA.25

PubChem Substance ID:

57654693

EC Number:

202-739-6

Beilstein/REAXYS Number:

5322018

MDL number:

MFCD00071594

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Properties

biological source

Saccharomyces cerevisiae

Quality Level

300

assay

≥99% (HPLC)

form

powder

optical activity

[α]20/D 174 to 182 °, c = 7% (w/v) in water

technique(s)

HPLC: suitable, PCR: suitable, cell based assay: suitable, cryopreservation: suitable

impurities

≤5.0% EtOH, <20 ppm Trace metals

color

white

mp

97-99 °C

solubility

water: 50 mg/mL, clear, colorless

application(s)

advanced drug delivery
advanced drug delivery
agriculture
cell analysis
life science and biopharma
sample preparation

storage temp.

room temp

SMILES string

[H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1

InChI key

DPVHGFAJLZWDOC-PVXXTIHASA-N

Description

General description

Trehalose, also known as mycose or tremalose, is a nonreducing disaccharide of glucose commonly found in fungi, bacteria, and invertebrates. Its presence in these organisms highlights its significance in various biological processes and potential applications in biochemical research and cell culture studies.

Application

D-(+)-Trehalose dihydrate has been used:

as a transcription factor EB (TFEB) to study its effects on an autophagy-lysosomal system in human silicosis alveolar macrophages
as stabilizing excipient in spray-dried protein formulations
as a cryoprotectant to study its effects on mouse testicular cell suspensions

Biochem/physiol Actions

D-(+)-Trehalose shows anti-desiccant and cryopreservative activities. It acts as an osmolyte, and stress protectant and helps in the storage and transport of carbon. Trehalose is involved in the food, cosmetic, and pharmaceutical industries. It plays a vital role in the survival of certain insects and plants known as anhydrobionts during harsh environments such as high rates of dehydration.

Preparation Note

Prepared by ion exchange chromatography.

Analysis Note

Reduced metal ion content.

Other Notes

For additional information on our range of Biochemicals, please complete this form.

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Efficiency of Chitosan/Hyaluronan-Based mRNA Delivery Systems In Vitro: Influence of Composition and Structure.

Ousamah Younoss Soliman et al.

Journal of pharmaceutical sciences, 109(4), 1581-1593 (2020-01-01)

Messenger RNA (mRNA)-containing nanoparticles were produced by electrostatic complexation with a library of pharmaceutical grade chitosans with different degrees of deacetylation and hyaluronic acids (HAs) (native vs. sulfated). Polymer length (Mn), HA degree of sulfation (DS), and amine to phosphate

ATF4-Induced Warburg Metabolism Drives Over-Proliferation in Drosophila.

Sebastian Sorge et al.

Cell reports, 31(7), 107659-107659 (2020-05-21)

The mitochondrial electron transport chain (ETC) enables essential metabolic reactions; nonetheless, the cellular responses to defects in mitochondria and the modulation of signaling pathway outputs are not understood. We show that Notch signaling and ETC attenuation via knockdown of COX7a

Microheterogeneity in frozen protein solutions.

Alan Twomey et al.

International journal of pharmaceutics, 487(1-2), 91-100 (2015-04-19)

In frozen and lyophilized systems, the biological to be stabilized (e.g. therapeutic protein, biomarker, drug-delivery vesicle) and the cryo-/lyo-protectant should be co-localized for successful stabilization. During freezing and drying, many factors cause physical separation of the biological from the cryo-/lyo-protectant

View All Related Papers

Global Trade Item Number

SKU	GTIN
T9531-10MG	04061837381652
T9531-25G	04061835522668
T9531-5G	04061835550395
T9531-10G	04061835550364
T9531-25KG	04061832966625
T9531-500G	04061835550388
T9531-100G	04061835550357
T9531-2.5KG	04061835550371