Merck
CN
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文件

408727

Sigma-Aldrich

支化聚乙烯亚胺

average Mw ~25,000 by LS, average Mn ~10,000 by GPC, branched

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别名:
氮丙啶，均聚物, PEI
线性分子式:
H(NHCH2CH2)nNH2
CAS号:
9002-98-6
MDL编号:
MFCD00084427
PubChem化学物质编号:
24865591
NACRES:
NA.23

形式

viscous liquid

分子量

average Mn ~10,000 by GPC
average Mw ~25,000 by LS

杂质

≤1% water

折射率

n20/D 1.5290

粘度

13,000-18,000(50 °C)

bp

250 °C (lit.)

密度

1.030 g/mL at 25 °C

SMILES字符串

C1CN1

InChI

1S/C2H5N/c1-2-3-1/h3H,1-2H2

InChI key

NOWKCMXCCJGMRR-UHFFFAOYSA-N

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相关类别

一般描述

聚乙烯亚胺（PEI）是一种亲水性阳离子聚合物， 被广泛用作非病毒核苷酸转染试剂。支链PEI可以 通过氮丙环的阳离子开环聚合反应合成。PEI基 颗粒也可用作疫苗的助剂。由于其良好的 理化性质，它在许多领域中得到了应用，如 蛋白质的分离纯化、二氧化碳吸收、药物载体、 废水处理和生物标记。

应用

聚乙烯亚胺可用作非病毒合成聚合物载体，用于治疗性核酸的体内输送。 带负电荷的核酸和带正电荷的聚合物主链之间的相互作用导致纳米络合物的形成。这种中性络合物保护被包裹的核酸免于遭受酶的作用，并维持其稳定性直至发生细胞摄取。例如，与人血清白蛋白结合的PEI 具有良好的pDNA 转染性能和低毒性。

PEI可用于单壁纳米管 (SWNT) 的功能化修饰，以改善其溶解性和生物相容性，同时维持原始SWNT的结构完整性。共价功能化的SWNT可应用于 CO2 吸收和基因递送。

支链PEI也可用于改变吸附剂的表面性质。PEI修饰的水合氧化锆/PAN纳米纤维可用于地下水的脱氟，因为其具有高氟吸附能力和宽工作pH范围。

特点和优势

PEI的伯胺和仲胺基团可以高效地结合 药物、核酸和其它功能基团。

支链PEI 具有更好的络合和缓冲能力。

外形

支化聚合物

象形图

Exclamation markEnvironment
GHS07,GHS09

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

储存分类代码

10 - Combustible liquids

WGK

WGK 2

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the concentration and purity of Polyethylenimine, Product 408727?

    This product is the pure product of polyethyleneimine. At room temperature this product is a liquid and not a solid. The purity of this product is not routinely determined.

  4. At what temperature does Product 408727, Polyethylenimine, decompose?

    Polyethylenimine (mw ~25,000) begins to decompose at 225 °C.

  5. What is the solubility of Product 408727, Polyethylenimine?

    We do not test the solubility of this product.  However, according to our supplier, this product is miscible with water and ethylene glycol, and soluble in ethanol.

  6. What are the end groups on Product 408727, Polyethylenimine?

    The end groups are primary, secondary, and tertiary amines that are in a ratio of 1 : 1.2 : 0.76, respectively.

  7. What is the water content of Product 408727, Polyethylenimine?

    This product will contain less than 1% water. The lot specific value is reported on the Certificate of Analysis.

  8. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  9. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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As an immunotoxin, diphtheria toxin has been widely used in gene therapy and gene function assays for its roles in protein synthesis inhibition, and the aim of our study is to set up a nonintegrating lentiviral system for specific expression
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