Solid phase extraction

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facet applications:Solid phase extraction

facet content type:Technical Article

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Solid Phase Extraction: Reversed-Phase Methodology

Reversed-phase interaction will retain most molecules with hydrophobic character; it is very useful for extracting analytes that are very diverse in structure within the same sample.

Ion-Suppression & Phospholipid Contamination

We are presenting an article focusing on ion-suppression and phospholipid contamination and some of their major causes and difficulties.

Chiral and Achiral LC-MS Analysis of Warfarin™ in Plasma Samples

Clinical laboratories are beginning to reap the benefits of LC-MS in terms of its sensitivity, specificity, throughput, and potential to reduce cost per sample. The purpose of this study was to demonstrate the LC-MS analysis of Warfarin in plasma samples

Supel™-Select Polymeric SPE

Supel-Select HLB SPE - a hydrophilic modified styrene based polymer developed for the solid phase extraction of a broad range of compounds from aqueous samples.

LC/MS/MS法测定谷物中的草甘膦、AMPA和草铵膦

使用 HPLC 和 SPE 的离子交换聚合物基颗粒测定燕麦片和婴儿谷物中的草甘膦及相关化合物。获得低水平的检测结果。

Solid Phase Extraction: Ion Exchange Methodology

SPE retention mechanism in this case is based on the electrostatic attraction of charged functional groups of the analyte(s) to oppositely charged functional groups on the sorbent.

Ion-Exchange SPE Methodology

Normal-Phase Methodology in Solid Phase Extraction Microbiology. In order g003572 for polar retention to occur between the sorbent and the sample, the analyte must be introduced to the SPE device in a non-polar sample or mobile phase environment.

离子交换方法

离子交换法在固相萃取中的应用、抗衡离子选择性和离子交换及基本步骤。

Quick, Sensitive LC/MS/MS Analysis of Aflatoxins in Cannabis

Analyte recovery values from spiked cannabis extracts ranged from 102 to 127% with RSD below 12% for 3 replicates. Excellent recovery values were even observed for Aflatoxins B2 and G2 which were spiked at a low level of 6.1 ppb.

Fast and Accurate Analysis of Vitamin D Metabolites Using Novel Chromatographic Selectivity and Sample Preparation

Vitamin D deficiency has become a topic of interest in recent publications. Vitamin D regulates the absorption of calcium within the digestive track and is important to promote proper bone growth and prevent osteoprosis in older adults.

Method Optimization for LC-MS Analysis of Vitamin D Metabolite Critical Pairs in Serum

Novel sample prep technique coupled with the unique selectivity of the Ascentis Express F5 column enables a fast and simplified bioanalytical method for associated vitamin D metabolites.

Isolation and LC-MS Characterization of Illicit Bath Salts in Urine

The combination of ion-exchange SPE with the HILIC HPLC separation provides a novel approach for the testing of problematic bath salt compounds.

Molecularly Imprinted Polymer SPE- Acid NSAIDs from Muscle

A new, successfully developed and validated LC-MS-MS method allowing the extraction of NSAIDs from poultry muscle tissue using Molecularly Imprinted Polymer (MIP) SPE.

Mixed-Mode SPE Improves Extraction of Pharmaceutical Compounds from Biological Fluids

HybridSPE®-Phospholipid Technology

Innovative solid phase extraction (SPE) technology from Supelco, utilizes phospholipid retention mechanism based on highly selective interaction between proprietary zirconia ions (bonded to the stationary phase) and the phosphate moiety consistent with phospholipids and proteins.

Improvement in LC/MS Analysis of Vitamin D Metabolites in Serum by Leveraging Column Selectivity and Effective Sample Prep

Replace Classical Liquid-Liquid Extractions with EXtrelut® NT

Simplify your liquid-liquid extractions with our emulsion-free supported-liquid extraction (SLE) single step solution.

使用分子印迹聚合物SPE提取安非他明及相关药物

Molecularly Imprinted Polymer SPE Increases Sensitivity for the Extraction of Clenbuterol from Urine

Clenbuterol (Figure 1) is a beta-agonist known for its growth-promoting properties in which use of the drug induces significant weight gain by increa

HybridSPE-Phospholipid Technology

This Sigma-Aldrich article discusses how the HybridSPE-Phospholipid Technology works and how the phospholipids are removed.

Investigating Matrix Interference in Analysis of Antiarrhythmic Cardiac Drugs in Plasma

For efficient therapeutic drug monitoring, it is important for clinicians to have access to fast and robust analytical methods for accurate assessment of drug efficacy. Industrial trends toward highly specific LC/MS applications over traditional immunoassay have resulted in the need

SPE Cleanup of Wheat Extracts Prior to the HPLC Analysis of the Mycotoxin Deoxynivalenol

Supel Tox DON SPE cartridges required fewer process steps and fewer reagents than the IAC cleanup method for wheat matrix samples prior to HPLC analysis.

A Comparison of Two Solid Phase Extraction Methods for the Analysis of Polyaromatic Hydrocarbons in Butter

Analysis of PAHs in butter can pose a special challenge due to the high fat content and the lipophilic nature of PAHs.

Extraction of Nitroimidazoles from Milk and Eggs using Molecularly Imprinted Polymers

In this report, SupelMIP SPE – Nitroimidazoles was evaluated for the extraction of nitroimidazoles and metabolites from milk and egg.

Method Optimization for LC-MS Analysis of Vitamin D Metabolite Critical Pairs in Serum

Using HybridSPE-Phospholipid, Ascentis Express, and Other LC-MS Workflow Components

LC-MS BioAnalysis Small Molecules

When analyzing small molecules the overarching need is to maximize sensitivity without compromising reproducibility and laboratory throughput.

Online Solid Phase Extraction and LC/MS Analysis of Thyroid Hormones in Human Serum

An online SPE-LC/MS method has been developed for the rapid detection of thyroid hormones in human serum with minimal hands on effort and time-consuming steps.

Analysis of Pesticide Residues in Ginger Powder Using QuEChERS Extraction and Clean-up with a Novel Dual Layer SPE Cartridge

The odor and pungency of ginger is due to the presence of terpenes, gingerols and shogaols. These compounds contribute to the highly complex matrix of ginger, which subsequently presents a challenge in low level analyses of contaminants. A novel 2-layer

Vitamin D epi-Metabolites Separated with HybridSPE-Phospholipid

This Sigma-Aldrich article continues to detail new methodology for the analysis of Vitamin D metabolites using HybridSPE-Phospholipid technology.

Impact of Mobile Phase Additives on LC-MS Sensitivity, Demonstrated using Spice Cannabinoids

This study demonstrates the impact of various mobile phase modifiers on the separation; formate modifiers outperform acetate in terms of MS signals (or sensitivity) and chromatographic resolution.

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